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PROMOGRAN How does it work video

 


















References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

PROMOGRAN

  • Binds and inactivates proteases (MMPs and Elastase)1



















References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

PROMOGRAN

  • Binds and inactivates proteases (MMPs and Elastase)1
  • Protects growth factors2


















References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

PROMOGRAN

  • Binds and inactivates proteases (MMPs and Elastase)1
  • Protects growth factors2
  • Enhances granulation tissue formation3 
















References:
1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

PROMOGRAN is made up of 55% collagen and 45% oxidised regenerated cellulose. 



















References:
1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key

Key














References:
1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key

PROMOGRAN key
Wounds with Elevated Protease Activity (EPA)
4


















References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

 Key

PROMOGRAN key
Wounds with Elevated Protease Activity (EPA)
4

1) EPA in the wound made up of MMP and Elastase activity


















References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

 Key

PROMOGRAN key

Wounds with Elevated Protease Activity (EPA)4
1) EPA in the wound made up of MMP and Elastase activity
2) Growth factor activity is reduced due to being degraded by elevated protease activity















References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

 Key

PROMOGRAN key
Wounds with Elevated Protease Activity (EPA)
4

3) Wound is stalled due to degradation of the extra cellular matrix by elevated protease activity and reduced levels of growth factor activity












References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

 Key

PROMOGRAN key

PROMOGRAN is applied directly to the wound bed.

 













References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

 Key

PROMOGRAN key
PROMOGRAN is applied directly to the wound bed.
 

1) Dressing absorbs exudate including Proteases

















References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key

PROMOGRAN key
PROMOGRAN is applied directly to the wound bed.
 

1) Dressing absorbs exudate including Proteases
2) Collagen deactivates MMPs














References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key

PROMOGRAN key
PROMOGRAN is applied directly to the wound bed.
 

1) Dressing absorbs exudate including Proteases
2) Collagen deactivates MMPs 
3) ORC deactivates Elastase















References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key

PROMOGRAN key
1) 
Deactivation of proteases helps to protect the growth factors, which stimulates healing.















References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

 

Key

PROMOGRAN key

1) Deactivation of proteases helps to protect the growth factors, which stimulates healing.
2) Deactivation of proteases helps to protect the newly formed ECM from their damaging activity, encouraging proliferation.

 














References:
1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

 

Key

PROMOGRAN key

PROMOGRAN promotes tissue growth and wound surface area reduction.


















References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key

PROMOGRAN key

Carefully remove the secondary dressing and cleanse the wound. It is not necessary to remove any residual PROMOGRAN during dressing changes. 

© Copyright Systagenix 2012. All Rights Reserved. 














References:

1. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of Collagen/ORC. Wound Repair Regen. 2004 12(2) A4. (this won the blue ribbon award at WHS meeting)
2. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
3. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570
4. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

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