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PROMOGRAN PRISMA How does it work video




















References

11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

PROMOGRAN PRISMA

  • Binds and inactivates proteases (MMPs and Elastase)1





















References

11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

PROMOGRAN PRISMA

  • Binds and inactivates proteases (MMPs and Elastase)1
  • Protects growth factors2 






















References

11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

PROMOGRAN PRISMA

  • Binds and inactivates proteases (MMPs and Elastase)1
  • Protects growth factors2 
  • Reduces bacterial growth, providing protection from infection3,4





















References

11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

PROMOGRAN PRISMA

  • Binds and inactivates proteases (MMPs and Elastase)1
  • Protects growth factors2 
  • Reduces bacterial growth, providing protection from infection3,4
  • Enhances granulation tissue formation3 




















References

11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

PROMOGRAN PRISMA is made up of 
55% Collagen, 44% Oxidised Regenerated Cellulose and 1% Silver/ORC.
 





























References
11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key
key
Wounds with Elevated Protease Activity (EPA)4















References

11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key
key
Wounds with Elevated Protease Activity (EPA)4
1) Elevated protease activity (EPA) in the wound made up of MMPs and Elastase
















References

11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key
key
Wounds with Elevated Protease Activity (EPA)4
1) Elevated protease activity (EPA) in the wound made up of MMPs and Elastase

2) Bacteria in the wound  may increase the risk of developing an infection















References

11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key
key
Wounds with Elevated Protease Activity (EPA)4
3) Growth factor activity is reduced due to being degraded by elevated MMPs and Elastase















References

11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

 

Key
key
Wounds with Elevated Protease Activity (EPA)4
3) Growth factor activity is reduced due to being degraded by elevated MMPs and Elastase
4) Wound is stalled due to degradation of the extra cellular matrix and growth factors (lack of healthy looking granulation tissue)















References

11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

 

 

Key
key

PROMOGRAN PRISMA
 is applied directly to the wound bed. Cover with a secondary dressing such as TIELLE.















References

11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key

key
1) Dressing absorbs exudate including Proteases













References
11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key

key
1) Dressing absorbs exudate including Proteases
2) Collagen deactivates MMPs












References
11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key

key
1) Dressing absorbs exudate including Proteases
2) Collagen deactivates MMPs
3) ORC deactivates Elastase 











References
11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

 

Key

key
Ag) Silver/ORC is bactericidal, killing the bacteria











References
11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

 

Key

key
1) Deactivation of proteases helps to protect the growth factors, which stimulates healing.











References
11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key

key
1) Deactivation of proteases helps to protect the growth factors, which stimulates healing.
2) Deactivation of proteases helps to protect the newly formed ECM from their damaging activity, encouraging proliferation.










References
11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Key

key
1) Deactivation of proteases helps to protect the growth factors, which stimulates healing.
2) Deactivation of proteases helps to protect the newly formed ECM from their damaging activity, encouraging proliferation.
3) Destruction of bacteria provides antimicrobial protection against bacterial colonisation which could lead to full blown infection and hinder healing.









References
11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

 

Key

key
1) Deactivation of proteases helps to protect the growth factors, which stimulates healing.
2) Deactivation of proteases helps to protect the newly formed ECM from their damaging activity, encouraging proliferation.
3) Destruction of bacteria provides antimicrobial protection against bacterial colonisation which could lead to full blown infection and hinder healing.
4) Collagen/ORC/Silver helps to promote tissue growth and wound surface area reduction, whilst providing antimicrobial protection.











References
11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Carefully remove the secondary dressing and cleanse the wound. It is not necessary to remove any residual PROMOGRAN during dressing changes.















References
11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

Carefully remove the secondary dressing and cleanse the wound. It is not necessary to remove any residual PROMOGRAN during dressing changes.

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References
11. Cullen et al. Use of oxidized regenerated cellulose in facilitating wound healing. Presented at EWMA 2010
2. Data presented by R. Snyder at EWMA 2009 – Finland
3. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
4. Smeets R, Ulrich D, Unglaub F, Woltje M, Pallua N. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int Wound J 2008;5:195-203.
5. Gottrup F, et al. Comparative clinical study to determine the effects of Collagen/ORC + Silver therapy on wound healing of diabetic foot ulcers. Presentation at EWMA 2010, Geneva.
6. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

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